HomePublicationsDupud, R., Thushara, R., Merugu, K. K., Suresh, C. H., & Ramesh, R. (2024). Radical Cascade Annulation of Biphenyl Acrylamides to Dibenzoazepinones: Experimental and DFT Studies. European Journal of Organic Chemistry. Dupud, R., Thushara, R., Merugu, K. K., Suresh, C. H., & Ramesh, R. (2024). Radical Cascade Annulation of Biphenyl Acrylamides to Dibenzoazepinones: Experimental and DFT Studies. European Journal of Organic Chemistry.By Web / October 5, 2024 https://doi.org/10.1002/ejoc.202400450. Abstract:An efficient method for the conversion of biphenyl acrylamides to dibenzoazepinones with -SCF3 incorporation is described. This operationally simple radical cascade reaction employs CAN as an oxidant and exhibits good functional group tolerance. Substrates featuring -OCH3, -CH3, -Br or -Cl at the para-position of the aromatic ring exhibits a preference for an ipso-cyclization due to the intervention of DMSO in the reaction. Density functional theory (DFT) calculations provide valuable insights into the reaction’s energetics and product selectivity.
